An overview of Nux vomica extract

In conventional and homoeopathic medicine, nux vomica—an extract from the seeds of the Strychos nux-vomica, or strychnine tree—is used to treat a variety of ailments, such as cancer and heart disease. Strychnine and brucine, two poisonous alkaloids that are prohibited or severely restricted in most countries, are found in Nux vomica. The symptoms of Nux vomica toxicity include convulsions, rhabdomyolysis, metabolic acidosis, respiratory and cardiac arrest, and neuromuscular hyperexcitability accompanied by agitation and muscle spasms.

The Strynos nux-vomica tree, which is indigenous to Southeast and India, is used to make nux vomica. In Ayurvedic and traditional Asian medicine, the dehydrated, processed seeds have been used to treat a wide range of ailments, such as cancer, heart disease, constipation, arthritis, influenza, and musculoskeletal issues. On the other hand, significant amounts of the alkaloid toxins brucine and strychnine are also present in Nux vomica seeds. Strychnine is a well-known toxin that is only used as bait to kill wild animals like rats and moles. Because it is linked to both deliberate and unintentional poisoning, it is prohibited or restricted in most nations across the world. Although strychnine and brucine have antioxidant, anti-inflammatory, and anti-tumor action in cell culture, their therapeutic window is small, and they have not been demonstrated to have any positive medical effects in human trials.

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